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Perspectives in Diabetes
  1. Hugo Fitipaldi1,
  2. Mark I. McCarthy2reverses diabetes type 2 doctor near me (🔴 vitamind3) | reverses diabetes type 2 young agehow to reverses diabetes type 2 for the 1 last update 27 May 2020 ,,3,
  3. Jose C. Florez4,5,6 and
  4. Paul W. Franks1,2,7,8
  1. 1Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden
  2. 2Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.
  3. 3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
  4. 4Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA
  5. 5Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA
  6. 6Department of Medicine, Harvard Medical School, Boston, MA
  7. 7Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA
  8. 8Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
  1. Corresponding author: Paul W. Franks, reverses diabetes type 2 treatment side effect (👍 questionnaire) | reverses diabetes type 2 diagnostichow to reverses diabetes type 2 for paul.franks{at}med.lu.se.
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Abstract

The detailed characterization of human biology and behaviors is now possible at scale owing to innovations in biomarkers, bioimaging, and wearable technologies; “big data” from electronic medical records, health insurance databases, and other platforms becoming increasingly accessible; and rapidly evolving computational power and bioinformatics methods. Collectively, these advances are creating unprecedented opportunities to better understand diabetes and many other complex traits. Identifying hidden structures within these complex data sets and linking these structures to outcome data may yield unique insights into the risk factors and natural history of diabetes, which in turn may help optimize the prevention and management of the disease. This emerging area is broadly termed “precision medicine.” In this Perspective, we give an overview of the evidence and barriers to the development and implementation of precision medicine in type 2 diabetes. We also discuss recently presented paradigms through which complex data might enhance our understanding of diabetes and ultimately our ability to tackle the disease more effectively than ever before.

Introduction

The etiology, clinical presentation, and consequences of type 2 diabetes can vary greatly from one patient to the next, complicating the prevention and management of the disease. The cardinal feature of type 2 diabetes is chronically elevated blood glucose concentrations; however, to categorize it as “type 2 diabetes,” the clinician must exclude autoimmunity, pregnancy, pancreatic disease or injury, and rare syndromic or genetic forms of diabetes. In addition to assessing the signs and symptoms of diabetes, the clinician uses high-level data about the patient, such as their age, family history, ethnicity, mental health, medications, biochemical profile, lifestyle, and body weight, to understand the nature of the disease and in turn to help optimize treatment. The fact that type 2 diabetes is diagnosed on the basis of exclusion speaks to the lack of mechanistic understanding we have of the disease and the absence of assays that detect the underlying defect(s) rather than its biochemical consequence (elevated glucose).

In Western health care systems, diabetes treatment follows an algorithmic sequence that starts with lifestyle modification + metformin (absent contraindications) and later may progress to other drugs and/or insulin, while monitoring tolerability and glycemic goals to determine if the next step in the sequence should be taken. Lifestyle modification alone is usually unsuccessful and even with combined drug therapy about one-third of patients with diabetes in the U.S. eventually require exogenous insulin (1).

The emergence of type 2 diabetes as one of the major causes of morbidity and premature mortality is closely linked to widespread adoption of obesogenic (Westernized) lifestyles. This relationship is likely to be causal, as aggressively intervening on lifestyle factors that promote and/or help maintain weight loss delays the onset of diabetes in high-risk adults (25) and about half of patients undergoing medium-term hypocaloric diet interventions leading to major weight loss (≥15 kg) achieve medication-free diabetes remission within a year (6). Diabetes remission is also common in patients who experience major weight loss with bariatric surgery (7). The population-scale decline in rates of obesity, diabetes, and cardiovascular disease during economic crises that have forced entire populations to increase physical activity levels and reduce caloric intake reinforces the role of negative energy-balance in diabetes prevention (8).

The proven benefits of lifestyle modification in diabetes prevention and the effectiveness of several diabetes drugs are counterbalanced by the continuing emergence of type 2 diabetes as one of the most prevalent and burdensome diseases globally (9). In the U.S. for example, diabetes was the seventh leading cause of death in 2010, accounting for at least 10–15% of deaths in people aged ≥20 years, with adult death rates ∼50% higher in people with diabetes than in those without (1). The economic burden of diabetes is also formidable, with diabetes costing the U.S. economy about US$245 billion in 2012, with the average annual medical costs per patient with diabetes more than double those for people without the disease (1).

The rising prevalence of diabetes on a population scale and the insufficiency of established therapeutic options justify the search for orthogonal diabetes prevention and treatment strategies to complement existing approaches. Ideally, these new approaches would be better tailored to the individual for enhanced tolerability and effectiveness.

This drive to develop precision medicine for diabetes is predicated on the major technological advances seen in recent years that include high-resolution ‘omic assays, wearable devices that monitor behaviors and exposures, and digital imaging technologies. The intelligent integration of the data these technologies yield can provide detailed digital impressions of a person’s physical condition, their past exposure and ongoing susceptibility for 1 last update 27 May 2020 to certain risk factors, and how they might respond to specific antidiabetes therapies, as well as help track disease progression. All of this has the potential to substantially improve the prediction, prevention, and treatment of type 2 diabetes, and there are, as discussed later, many major initiatives under way with this objective. However, as also discussed, there is much to resolve before precision diabetes medicine becomes common practice.This drive to develop precision medicine for diabetes is predicated on the major technological advances seen in recent years that include high-resolution ‘omic assays, wearable devices that monitor behaviors and exposures, and digital imaging technologies. The intelligent integration of the data these technologies yield can provide detailed digital impressions of a person’s physical condition, their past exposure and ongoing susceptibility to certain risk factors, and how they might respond to specific antidiabetes therapies, as well as help track disease progression. All of this has the potential to substantially improve the prediction, prevention, and treatment of type 2 diabetes, and there are, as discussed later, many major initiatives under way with this objective. However, as also discussed, there is much to resolve before precision diabetes medicine becomes common practice.

How Precision Diabetes Medicine Might Work

The foundation of precision medicine in type 2 diabetes, like all other complex diseases, is population genetics, the catalyst for which was the sequencing of the human genome, a US$3 billion initiative that completed its work in 2003 (10). The availability of human genome sequences provided a framework that facilitated the design of massively parallel, chip-based genotyping arrays. These technologies have since been used to characterize common genomic variation in millions of people worldwide, which in turn has helped identify hundreds of variants associated with type 2 diabetes and related traits through genome-wide association studies (GWAS) (11). The development of biotechnologies designed for high-resolution characterization of other types of biological variants (transcripts, proteins, epigenetic marks, metabolites, microbiota, etc.) has followed, further expanding our ability to map the paths that link a person’s biological idiosyncrasies to disease susceptibility. Although this work has primarily involved hypothesis-free association studies in large cohort collections, and thus the results are highly descriptive and of minimal relevance to the individual patient, it has provided substrate for functional studies, revealing novel aspects of disease biology and therapeutic targets that may seed individualized therapies.

It is generally accepted that precision medicine, informed by diverse sources of big data, will improve prevention and treatment of common, multifactorial diseases, such as type 2 diabetes, but there are few examples to date. The common variants shown by GWAS to be associated with type 2 diabetes have at best modest effect sizes, and the consensus view has historically been that, even in combination, their predictive value is limited, particularly when compared with the performance of classic risk factors such as age, BMI, and blood glucose (12). In the past year, however, there has been a reinvigoration of interest in the translational potential offered by genetic risk scores (13). Recent expanded GWAS data sets have yielded loci that explain a sizable proportion (50%) of diabetes heritability and highlight that there are millions of people (in the U.K. or U.S.) who, on the basis of genetic evidence alone, have very high (∼50%) lifetime risks of type 2 diabetes (14). This raises the prospect that the rollout of medical genotyping and sequencing will provide clinically actionable information on diabetes risk, particularly if genetic information is combined with other relevant clinical or exposure data.

So far, however, the clinical application of genetics in diabetes remains limited to rare, monogenic subtypes. Models for the personalization of type 2 diabetes care (especially in relation to exploiting the marked clinical heterogeneity within type 2 diabetes) have often extrapolated from this experience to invoke quasi-Mendelian scenarios characterized by distinctive subtypes of type 2 diabetes, each of which has the potential to be mapped to a specific remedial therapy or intervention. In reality, effective strategies in this area must address the multifactorial etiology of type 2 diabetes and a continuous spectrum of predisposition mediated, in most individuals, through joint effects across multiple pathways.

One recently described conceptualization of the pathophysiological architecture of type 2 diabetes predisposition (termed the “palette model”) focuses attention instead on the intermediary processes contributing to type 2 diabetes risk (15). The most obvious of these include obesity, fat distribution, islet development and function, and insulin sensitivity, but other, as-yet poorly characterized contributors are likely. Each of these processes is itself under multifactorial (genetic and nongenetic) control and individual “loadings” across them combinatorially influence both diabetes risk and the phenotype of any diabetes that results. Several recent studies (1619) have added empirical support for this approach, demonstrating, for example, differential relationships between process-specific risk scores and the risk of complications such as diabetic kidney disease and coronary artery disease.

The palette model captures the range of diabetes subtypes (from monogenic via hybrid forms [e.g., latent autoimmune diabetes in adults] through to the clinical heterogeneity evident within type 2 diabetes) as a continuum consistent with the genetic architecture of diabetes and real-world clinical observation (20,21). The model suggests that for many people with type 2 diabetes, their condition is the consequence not of a major defect in a single process but in the confluence of suboptimal performance across several processes contributing in parallel. This is what one would predict given the evidence that type 2 diabetes risk can be subtly modulated by common variants acting through any one of several distinct mechanisms (energy balance, adipocyte differentiation, incretin signaling, insulin secretion, etc.) and by the wide range of therapeutic interventions that have the proven capacity to ameliorate, to some degree at least, the diabetic state (e.g., insulin sensitizers, β-cell secretagogues, calorie restriction, exercise, and metabolic surgery).

This model provides a framework for understanding the mechanistic basis of heterogeneity and its clinical for 1 last update 27 May 2020 consequences. It also allows for the existence of cases at the extremes of the distribution for which a targeted intervention might be particularly effective. Genetic risk scores that capture each of these processes may help to tease apart heterogeneity in phenotype, progression, and therapeutic response. They may allow identification, within the overall population, of subsets of selected individuals in whom the profile of genetic predisposition is dominated by defects in a single pathway, facilitating personalized, mechanism-specific interventions.This model provides a framework for understanding the mechanistic basis of heterogeneity and its clinical consequences. It also allows for the existence of cases at the extremes of the distribution for which a targeted intervention might be particularly effective. Genetic risk scores that capture each of these processes may help to tease apart heterogeneity in phenotype, progression, and therapeutic response. They may allow identification, within the overall population, of subsets of selected individuals in whom the profile of genetic predisposition is dominated by defects in a single pathway, facilitating personalized, mechanism-specific interventions.

Nevertheless, for multifactorial diseases like type 2 diabetes, where individual predisposition is influenced as much by nongenetic as genetic factors, there is an absolute limit to the clinical precision that genetics alone can provide. For precision medicine to flourish, this genetic information will need to be integrated with relevant measures of those aspects of the external and internal environment (the latter term, for example, encompassing the gut microbiome) that also influence type 2 diabetes predisposition, phenotype, and progression. This information would ideally be supported by pertinent biomarker and clinical readouts, generating integrated profiles that may provide the predictive accuracy needed for clinical utility.

Along these lines, Ahlqvist et al. (20) used data from 8,980 Swedish patients with newly diagnosed diabetes (of any type) and applied machine learning algorithms to derive a data-driven approach to classifying diabetes subtypes. The authors proposed five subtypes determined by variations across six variables (glutamate decarboxylase antibodies, age at diagnosis, BMI, HbA1c, and HOMA2 estimates of β-cell function and insulin resistance). The relationship of subtype and incident events (use of antidiabetes medication, achievement of treatment goals, and diabetes complications) were assessed and replicated in independent cohorts. Each cluster was characterized by certain phenotypic features assessed soon after diagnosis. These include early-onset severe autoimmune diabetes (6.7% of patients), severe insulin-deficient diabetes (17.5% of patients), severe insulin-resistant diabetes (15.3% of patients), mild obesity-related diabetes (21.6% of patients), and mild age-related diabetes (39.1% of patients). Rates of diabetic renal disease and coronary disease were highest in severe insulin-resistant diabetes, although rates of retinopathy were lowest for this group (retinopathies were more frequent in severe insulin-deficient diabetes). Severe insulin-resistant diabetes also progressed most rapidly to oral diabetes medications (other than metformin) and was the slowest to reach the HbA1c treatment goal <6.9% (52 mmol/mol). Both severe autoimmune diabetes and severe insulin-deficient diabetes progressed to sustained insulin use considerably more quickly than the remaining clusters. By contrast, mild age-related diabetes and mild obesity-related diabetes were characterized by reasonably favorable profiles.

This initial step demonstrated that one can derive clusters from existing big data that make eminent physiological sense. One limitation of this approach though, in contrast with a genetically driven strategy, resides in the use of phenotypic criteria for clustering that are ascertained at disease onset and are not necessarily generalizable to the many people one would want to stratify (with normoglycemia or with advanced diabetes). One should also remain cognizant that a clinician may not be able to unequivocally place an individual patient into a given cluster; thus, the implementation and clinical utility of this approach remain to be demonstrated.

It will be essential to understand how the relationships between these genetic and physiological approaches to stratification might be combined and, in doing so, how much value is added from a clinical perspective. A crucial missing piece is evidence that by clustering patients in this way, disease course, diabetes complications, or treatment response can be predicted with sufficient accuracy to be of clinical value. This determination requires the explicit assessment of predictive accuracy and reclassification. Similarly, it is not known whether treatment that is guided by cluster identity will be more or less effective than current approaches, for which intervention studies will be needed. Moreover, because clustering techniques typically require the dichotomization of continuous exposure variables, which usually results in loss of power, the predictive accuracy of algorithms that do not require this type of data transformation is likely to be superior.

reverses diabetes type 2 in hindi (🔥 joint pain) | reverses diabetes type 2 oliveshow to reverses diabetes type 2 for Family history of diabetes is a strong predictor of disease and is frequently included in diabetes prediction algorithms. For information on family history to enhance the predictive ability of the phenotypic clusters proposed by Ahlqvist et al. (20), it would require that some clusters be more driven by familial factors than others. This may well be true, and future studies exploring the genetic basis of these clusters may help test this hypothesis. However, family history is the consequence of both genetic and environmental influences (including developmental exposures), and understanding why family history affects disease progression differentially across clusters, if indeed it does, would likely be intensely scrutinized owing to the etiological insights this might reveal.

Overview of Major Precision Medicine Initiatives

After the first draft sequence of the human genome was published in 2001 (10), methods and technologies were rapidly developed that enabled large-scale quantification of human genetic variation and subsequently variation across other biological strata. As investigators began using these technologies, global research consortia grew through which novel biomarkers for type 2 diabetes were discovered. The rapid growth of large data sets and ad hoc collaborative networks, as well as clear evidence that this new approach to biomarker discovery worked, laid the foundations for large precision medicine initiatives. Although some initiatives have built new cohorts from scratch, most have leveraged existing data and biomaterials already stored in biobanks (Table 1 and Fig. 1).

View this table:
Table for 1 last update 27 May 2020 1Table 1

Global precision medicine initiatives of relevance to type 2 diabetes

Figure 1

Global precision medicine initiatives of relevance to type 2 diabetes.

reverses diabetes type 2 nice (☑ rash) | reverses diabetes type 2 with hyperglycemiahow to reverses diabetes type 2 for In 2008, a joint undertaking between the European Commission, European academic institutions, and the European Federation of Pharmaceutical Industries and Associations was launched. This €5.6 billion program, called the Innovative Medicines Initiative (IMI), comprises ∼100 projects focused on the major diseases affecting European citizens. Of these, several focus on precision medicine in type 2 diabetes: SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) (diabetes complications), Diabetes Research on Patient Stratification (DIRECT) (drug response and glycemic deterioration before and after the onset of type 2 diabetes) (22), Risk Assessment and ProgreSsiOn of DIabetes (RHAPSODY) (glycemic deterioration before and after the onset of type 2 diabetes), and Biomarker Enterprise to Attack Diabetic Kidney Disease (BEAt-DKD) (diabetic kidney disease). A common objective is the discovery and validation of biomarkers that facilitate the stratification of patient populations into subgroups that might be treated more effectively than without biomarker stratification. In some instances, the focus is also on diagnostic reclassification. Unlike most other precision medicine initiatives, those within the IMI focus on the integration of multiple biomarkers, such as genotypes, transcripts, proteins, metabolites, and metagenomics sequences.

The UK Biobank cohort (established 2005) includes around 500,000 adults, the vast majority of whom have provided nonfasting blood samples and self-reported data on lifestyle, health, and well-being and have been genotyped using genome-wide arrays, and targeted metabolomic analyses are also under way. In subcohorts, more detailed phenotyping has been undertaken, such as MRI scans and physical activity monitoring. Research conducted using UK Biobank data, for example, has shown that genetic variants associated with obesity are likely to influence susceptibility to a range of modifiable lifestyle exposures (2326), which may have relevance to diabetes. Nevertheless, the very small magnitude of these effects and susceptibility to confounding (25) precludes the immediate translation of these findings into clinical practice. Alternatively, as UK Biobank accrues incident events of diabetes complications, the database is likely to become a powerful resource through which the prognostic value of stratifying populations into subgroups or determining how environmental risk factors differentially affect disease susceptibility by subgroup can be assessed.

Plans to implement precision medicine into U.S. medical practice accelerated in 2015 with the announcement of the Precision Medicine Initiative (PMI), for which US$215 million was initially budgeted by the federal government (27,28). In the short term, the the 1 last update 27 May 2020 PMI is focused on cancer, whereas in the longer term, all areas of health and health care will be studied, with specific emphasis placed on the discovery of predictive biomarkers for type 2 diabetes (28). A major feature of the PMI is a cohort of 1 million people and a research program called the All of Us Research Program. The cohort, supported by a US$55 million budget, is built around nationwide recruitment sites under the banner of the PMI Cohort Program. Managed access for accredited researchers to biobanked data and samples is intended to facilitate several major goals, including those related to gene–environment interactions, pharmacogenomics, risk stratification, mobile health technologies, health empowerment, and innovative clinical trials (https://allofus.nih.gov).Plans to implement precision medicine into U.S. medical practice accelerated in 2015 with the announcement of the Precision Medicine Initiative (PMI), for which US$215 million was initially budgeted by the federal government (27,28). In the short term, the PMI is focused on cancer, whereas in the longer term, all areas of health and health care will be studied, with specific emphasis placed on the discovery of predictive biomarkers for type 2 diabetes (28). A major feature of the PMI is a cohort of 1 million people and a research program called the All of Us Research Program. The cohort, supported by a US$55 million budget, is built around nationwide recruitment sites under the banner of the PMI Cohort Program. Managed access for accredited researchers to biobanked data and samples is intended to facilitate several major goals, including those related to gene–environment interactions, pharmacogenomics, risk stratification, mobile health technologies, health empowerment, and innovative clinical trials (https://allofus.nih.gov).

Several other major U.S. initiatives predate the PMI and have diabetes and its risk factors at their core. These include the Million Veteran Program (MVP) and the Accelerating Medicines Partnership in Type 2 Diabetes (AMP T2D). The MVP uses genomics and other health data obtained through electronic medical records and follow-up surveys in about 600,000 military veterans aged 50–69 years (29). The AMP T2D seeks to gather genomic and metagenomic data and to create an analytical engine that can be used to mine the genetic basis to diabetes and related traits, while safeguarding the confidentiality of the results. Data access is a central pillar of AMP T2D and through the T2D Knowledge Portal (www.type2diabetesgenetics.org) the consortium has assembled genetic and phenotypic data from participants with and without type 2 diabetes from multiple populations, creating a central repository for such data (www.type2diabetesgenetics.org/informational/about). The ability of these initiatives to contribute to precision diabetes medicine is likely to be enhanced by their partnerships with industry, which are necessary to translate research into therapeutics approved by the U.S. Food and Drug Administration (FDA).

The Nordic countries have a long history of biobanking and registry-based research and have contributed substantially to discoveries in diabetes genetics over the past decade. In 2015, the Nordic Precision Medicine Initiative (NPMI) was formed to bring together genetic and other biomedical data from >1 million Nordic citizens. Several national precision and genomic medicine projects are under way: in Estonia, for example, the Estonian Genome Center at the University of Tartu is curating a population-based biobank suitable for precision medicine research in diabetes and other complex diseases. The aim is to promote and advance the development of genetic research and the implementation of genomic data into clinical practice to improve public health. The Estonian government recently launched the Estonian Personalised Medicine Pilot Project (EPMPP) (2015–2018), which seeks to implement personalized medicine on a national scale. Accordingly, the government has provided US$5.9 million to support genotyping in 100,000 Estonians. In Finland, the FinnGen project was launched in 2017 with the objective to link genomic data with digital health care data for 500,000 Finnish citizens (10% of the country’s population) through a public–private partnership. In Sweden, GAPS (Genomic Aggregation Project in Sweden) has assimilated >160,000 genotyped samples with corresponding phenotype data covering a wide range of diseases, including diabetes (30), and GMS (Genomic Medicine Sweden) is spearheading clinical genomics on a national scale. In Iceland, the company deCODE genetics has established a genetic and phenotype database that encompasses the entire population (n = 334,000), which fuels genetics research and drug target validation for a wide range of diseases, including diabetes.

reverses diabetes type 2 life expectancy (🔥 symptoms mayo clinic) | reverses diabetes type 2 cookbookhow to reverses diabetes type 2 for Several other countries have launched large-scale programs of research on genomic and precision medicine, many with clear paths to clinical application although often only in relation to rare pediatric diseases. In Saudi Arabia, the very high prevalence of type 2 diabetes (∼20%) led the Saudi government and King Abdulaziz City for Science and Technology to initiate the Saudi Human Genome Project (SHGP), which seeks to sequence the genomes of 100,000 Saudi citizens in order to identify the genetic basis of monogenic and complex diseases like type 2 diabetes. In China, which has become a formidable force in decoding genomes (31), the government announced in 2016 a bold initiative to become a global superpower in precision medicine, with a US$9 billion, 15-year precision medicine initiative (32). The Chinese initiative has three core objectives, focused on recruiting 1) millions of participants from the seven main regions of China to form a nationally representative cohort, 2) eight disease-specific cohorts (cardiovascular, cerebrovascular, respiratory, metabolic, neurological, psychosomatic, immune system disorders, and seven common malignant tumors) totaling 700,000 participants, and 3) a clinical cohort (N = 50,000 patients with 50 rare diseases) (33).

Clinical Translation

The practice of precision diabetes medicine is currently confined to rare monogenic forms of the disease. Nevertheless, individual variants present only in specific population isolates have been discovered that may have clinical value in the prevention or treatment of type 2 diabetes. These include a TBC1D4 nonsense variant (p.Arg684ter) of relatively high prevalence in Greenlandic Inuit (minor allele frequency 17%) and other circumpolar Inuit populations that predisposes a substantially increased risk of diabetes (odds ratio >10 in those homozygous for the variant) (34). The mechanism of action involves the muscle-selective loss of the long TBC1D4 isoform and diminished GLUT4-mediated cellular glucose uptake in response to insulin. A thymine for cytosine substitution that causes a premature stop at codon 363 of TBC1D4 has also been discovered in people with acanthosis nigricans; the mutation causes postprandial hyperinsulinemia as a possible consequence of a specific muscle and adipose tissue insulin resistance (35).

In Latinos, a low frequency (minor allele frequency = 2.1% in people with type 2 diabetes) missense variant (p.E508K) at HNF1A conveys a type 2 diabetes odds ratio >5 (36). HNF1A also harbors mutations that cause rare monogenic diabetes that can be successfully treated with sulfonylureas (discussed later), suggesting this is true for the nontrivial number of Latino individuals with type 2 diabetes who carry p.E508K. Despite the relatively large effects these variants convey, whether they will prove useful in the context of precision medicine is unknown, as no formal assessment of clinical utility or cost-effectiveness has been reported.

Metformin was discovered in the 1960s and is currently the frontline drug for early-stage diabetes treatment, although its mechanisms of action remain unclear (37). There is genetic evidence for metformin intolerance (38), although this has not been widely replicated. By contrast, variants at ATM (39) and SLC2A2 (encoding GLUT2) (40) have been associated at a genome-wide level of statistical significance with metformin response. Although the effects conveyed by these variants are too small to guide patient-level treatment decisions, these findings may prove valuable in determining metformin’s mechanisms of action.

Many major precision medicine statements, including the executive summary of the U.S. PMI (28) and a National Research Council report focused on precision medicine and new disease taxonomies (41), make clear that research and practice in precision medicine should consider the major impact of lifestyle in disease etiology, prevention, and treatment. The incorporation of lifestyle into precision diabetes medicine is adequately justified by its proven benefits in diabetes prevention and treatment. Yet, there is good evidence that people benefit to varying degrees from diet and exercise and that personal biology underlies this (42). Thus, if precision medicine programs are to adequately consider the impact of lifestyle and other environmental exposures, it seems logical that emphasis should be placed on improving the precision of not only drugs but also this type of antidiabetes therapy too.

One compelling example of how glycemic response to food can be predicted using an individual’s biomarkers comes from a study of 800 young adults whose gut metagenomic sequences were ascertained and diet and blood glucose variation (from continuous glucose monitors) were monitored for a week (43). Each participant received one standardized meal (50 g carbohydrate) daily. The authors observed that although participants elicited different postprandial glycemic responses, the responses to the same food were consistent within individuals. Using machine learning algorithms, these data were used to predict each participant’s postprandial glycemic response to a given food. They subsequently administered tailored diet interventions to modulate glucose levels, providing proof of concept that personalized diets, guided by biomarker profiling, can reduce blood glucose variability. Notwithstanding the importance of this work from a basic science perspective, to determine its value for precision medicine requires knowing if minimizing variations in glucose in healthy adults is clinically relevant and whether the approach to predicting glycemic response to food also works in people with diabetes. To date, neither of these important questions is addressed in the published literature.

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Notwithstanding the relative dearth of funding for lifestyle medicine, some key initiatives exist. One of the largest of these is the National Institutes of Health’s Common Fund initiative on the Molecular Transducers of Physical Activity in Humans (http://commonfund.nih.gov/MolecularTransducers), which seeks to determine “optimal physical activity recommendations for people at various stages of life and develop “precisely targeted [exercise] regimens for individuals with particular health needs” (47). Elsewhere, the Food4Me study, a research program funded by the European Union, explored the role of genetics in the personalization of diet; data from the study suggest that personalized diet interventions supported by genetic data improve consumption of healthy foods (48) and help sustain healthy food choices (49). Interestingly, most loci selected for this intervention (variants at MTHFR, FTO, TCF7L2, APOE, and FADS1) lack evidence of individual-level clinical relevance (50), suggesting that the success of the Food4Me intervention was not dependent on the quality of the genetic information provided to participants.

Although most, if not all, precision medicine initiatives are predicated on the assumption that their findings will help improve people’s health, the emphasis of these initiatives is almost always on the generation of new knowledge. MVP, for example, seeks “to improve understanding of how health is affected by genetic characteristics, behaviors, and environmental factors” (29). Although this objective will undoubtedly be achieved, how this information will eventually be used to optimize prevention and treatment of diabetes and other diseases is unclear. Indeed, few precision medicine initiatives focused on complex diseases provide a clear plan for clinical translation (Fig. 2).

Figure 2

The path to precision medicine in type 2 diabetes. HEA, health economic assessment.

Potential Bottlenecks on the Path to Precision Medicine

Cost-effectiveness

The global precision medicine market was valued at US$43.6 billion in 2016 and is predicted to triple in value within the next decade (51). The economic dynamics associated with precision medicine differ from those of conventional medicines, as the nature of the approach means that precision medicines are likely to be approved for use only in specific subpopulations, limiting the number of patients eligible for treatment with a given drug. By contrast, the effectiveness of precision medicines should be higher for patients within these subpopulations than for conventional medicines, and side effects may be fewer and less severe. Owing to the smaller market share for a given precision medicine, competition to produce cheaper drugs between manufacturers may be less than for conventional drugs, and the drive to develop off-patent biosimilars (i.e., drugs with active properties identical or similar to previously licensed drugs) is likely to differ compared with conventional medicines, depending on the extent to which first-in-class drugs are undercut by cheaper alternatives. Collectively, these factors will impact the cost-effectiveness of precision medicines in type 2 diabetes (52).

Thus far, very few cost-effectiveness analyses in precision diabetes medicine have been published, despite long-standing recognition that cost-effectiveness is a key requirement for clinical translation (53). The rare examples of such studies have focused exclusively on rare monogenic forms of diabetes: neonatal diabetes (54) and maturity-onset diabetes of the young (MODY) (55,56).

reverses diabetes type 2 zhongwen (👍 would be considered) | reverses diabetes type 2 feethow to reverses diabetes type 2 for Neonatal diabetes is diagnosed in infancy and affects about 1:400,000 live births and roughly half (∼1:252,000 in people aged <20 years) develop permanent neonatal diabetes (54). Of the latter group, up to 70% are estimated to carry mutations in the genes encoding the ATP-sensitive potassium channel (KCNJ11 and ABCC8). These mutations block the closing of the KATP channels, which prevents β-cell depolarization and corresponding insulin secretion (57). However, treatment with sulfonylureas rectifies this defect in ∼90% of cases, allowing the discontinuation of exogenous insulin (58). The earliest cost–effect analysis in precision medicine focused on sulfonylurea therapy in permanent neonatal diabetes (54). The authors estimated that genetic testing in permanent neonatal diabetes would convey significant quality-of-life benefits at 10 years (0.32 quality-adjusted life-years; US$12,528 saved), increasing to 0.70 at 30 years (US$30,437 saved).

A range of single gene defects cause MODY, each of which are used to diagnose one of five forms of the disease. In MODY1 and MODY3, insulin secretion is impaired. The disease occurs early in life and is often misdiagnosed as type 1 diabetes, and exogenous insulin therapy is thus prescribed. However, treatment with sulfonylureas enables secretion of endogenously produced insulin. Switching from insulin to sulfonylureas is preferable for a number of reasons, including those related to safety and burden. MODY2 is caused by mutations in GCK, which lead to chronically elevated, but nonprogressive, blood glucose concentrations that do not typically require treatment; thus, diagnosing MODY2 also conveys reduced costs and burdens associated with unnecessary treatment. The first cost-effectiveness analysis focused on MODY1–3 in U.S. adults (aged 25–40 years) with diagnosed type 2 diabetes (56) based many of its assumptions on the findings of the UK Prospective Diabetes Study (UKPDS) (59). It also assumed a 2% frequency of MODY among people with diabetes and set genetic screening costs at US$2,580. Under these assumptions, genetic screening for MODY would not be cost-effective. The second study focused only on MODY1 screening and found that genetic screening was not cost-effective given the diabetes population frequency of MODY1 mutations is unlikely to exceed 2%. Substantial reductions in genetic sequencing costs may, however, render screening cost-effective (55).

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More than half of the most clinically impactful drugs developed recently were discovered through academia-led research (60), emphasizing the huge value of public–private partnerships. Many of the large precision diabetes medicine consortia involve both academia and industry within which unsurprising emphasis is placed on the discovery and validation of biomarkers that expedite drug development. This expectation is backed up by the proven ability of genetics to fast-track drug development by pinpointing high-value drug targets, helping halve drug failures and markedly reducing for 1 last update 27 May 2020 their costs (61). In drug repositioning, genetics has also proven its worth by revealing previously unknown conditions that a drug can be used to treat and by helping predict drug side effects.More than half of the most clinically impactful drugs developed recently were discovered through academia-led research (60), emphasizing the huge value of public–private partnerships. Many of the large precision diabetes medicine consortia involve both academia and industry within which unsurprising emphasis is placed on the discovery and validation of biomarkers that expedite drug development. This expectation is backed up by the proven ability of genetics to fast-track drug development by pinpointing high-value drug targets, helping halve drug failures and markedly reducing their costs (61). In drug repositioning, genetics has also proven its worth by revealing previously unknown conditions that a drug can be used to treat and by helping predict drug side effects.

To obtain FDA (or European Medicines Agency [EMA]) approval for biomarkers in medical products and devices involves a comprehensive qualification process (see https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DrugDevelopmentToolsQualificationProgram/BiomarkerQualificationProgram/ucm535395.htm), within which exists the requirement for a statement termed a “context of use.” The context of use statement requires a clear and detailed description of the intended role of the biomarker in drug development, as well as risks and benefits. The Foundation for the National Institutes of Health recently published the Framework for Defining Evidentiary Criteria for Biomarker Qualification (62), which provides an expanded outline of the biomarker classifications defined by the FDA.

The process of biomarker qualification in drug development requires stringent adherence to the relevant regulatory agencies’ approvals processes. In some studies that seek to discover biomarkers for diabetes drug development, the process is well rehearsed and aligning biomarker discovery and validation strategies with regulatory expectations is relatively straightforward; however, it does require that precision medicine consortia are well versed in these processes. Biomarker discovery in prediabetes is more challenging though, as prediabetes is not a distinct disease state, and although some people with prediabetes develop diabetes and its complications, a large proportion remains healthy for many years (63). Nevertheless, a subgroup of those with prediabetes will progress to diabetes and identifying these people before β-cell function is substantially diminished would open the door for several powerful therapeutics that are ineffective once endogenous insulin production has faded. However, because neither the FDA nor EMA currently recognizes an intermediate end point for disease progression in prediabetes drug trials, gaining regulatory approval for new prediabetes biomarkers requires that researchers foster close and frequent communications with the regulatory agencies to ensure candidate biomarkers have the possibility to progress through the regulatory process.

Legal, Social, and Ethical

Balancing the interests of society and its citizens, the risks and benefits, legislation and individual freedom, as well as the risk of exasperating disparities, is central to many commentaries on the legal, social, and ethical aspects of precision medicine.

Precision medicine research is heavily dependent on biobanked data and tissues. Often, the original informed consents were obtained many years before modern ‘omics technologies existed, at a time when many research questions germane to precision medicine were inconceivable. Often, the informed consents were broad, and ethics committees have concluded that these modern research questions are within the scope of the consents. As new, ever larger, and interconnected cohorts are being formed, the desire many researchers share for broad consenting and/or to bank data or samples for unspecified future research must be placed in context with several important ethical realities: the need to maintain participants’ confidentiality, appropriately handle incidental findings, determine who owns the samples and data, consider cultural sensitivities, return results to participants, engage society, and ensure unused material is properly disposed (64).

Much as precision medicine was inconceivable when many existing cohorts were formed, it is impossible to accurately predict how contemporary cohorts will be used in the future. Furthermore, many precision medicine initiatives involve the hybridization of academia, health care, and industry, which may challenge some of the more altruistic motivations of participants in academia-led biomedical research. Moreover, much of the highly sensitive data collated by these initiatives will eventually be made available through managed-access portals to a wide range of end users who were not part of the data collection process. Thus, much of this for 1 last update 27 May 2020 highly sensitive data will be widely disseminated and used by distant end users to address a plethora of diverse research questions that cannot yet be conceived, factors that need to be considered during the informed consent process. These are challenges for historical biobanks as well as new precision medicine cohorts that consent only at enrollment. To help overcome this, a process called dynamic consent has been developed, which allows consents to be progressively updated as projects evolve but requires fluid communication with participants throughout the life course of a study (65).Much as precision medicine was inconceivable when many existing cohorts were formed, it is impossible to accurately predict how contemporary cohorts will be used in the future. Furthermore, many precision medicine initiatives involve the hybridization of academia, health care, and industry, which may challenge some of the more altruistic motivations of participants in academia-led biomedical research. Moreover, much of the highly sensitive data collated by these initiatives will eventually be made available through managed-access portals to a wide range of end users who were not part of the data collection process. Thus, much of this highly sensitive data will be widely disseminated and used by distant end users to address a plethora of diverse research questions that cannot yet be conceived, factors that need to be considered during the informed consent process. These are challenges for historical biobanks as well as new precision medicine cohorts that consent only at enrollment. To help overcome this, a process called dynamic consent has been developed, which allows consents to be progressively updated as projects evolve but requires fluid communication with participants throughout the life course of a study (65).

reverses diabetes type 2 questions and answers (⭐️ weight gain) | reverses diabetes type 2 nature reviewhow to reverses diabetes type 2 for A major concern about genetic data are its linkage to databases that enables inferences about a person’s social, cognitive, moral, cultural, health, or sexual identity, which participants had not consented to, or for such inferences to be made about family members without their consent (64). Indeed, ensuring genomics data are used in a way consistent with appropriate ethical standards is a core feature of most current health data protection legislation (66). Notwithstanding these risks, there are major benefits associated with big data, which include the discovery of novel disease mechanisms and therapeutic targets, many of which only become visible when data sets scale to massive proportions. Thus, rather than constrain the growth and responsible utilization of big data, emphasis is being placed on implementing legislation that protects privacy and helps prevent data breaches, while facilitating the safe and responsible storage, transfer, and utilization of data. In the European Union, for example, the General Data Protection Regulation was implemented in May 2018 to harmonize data privacy laws across Europe. A key feature of this legislation as it relates to precision medicine research is that the analysis of sensitive data requires explicit opt-in consent, whereas for nonsensitive data, unambiguous (implied) consent is sufficient.

Summary and Conclusions

Diabetes medicine is likely to evolve dramatically in the coming years, ideally because evidence emerges from the major precision medicine initiatives to support its utility in preventing or treating diabetes, but no doubt also because of the major commercial interest in seeing precision medicine grow. One of the possible outcomes will very likely be the replacement of current classifications of diabetes with empirically derived subclassifications that can be coupled with treatment regimens, which, compared with conventional medicines, are more effective, less costly, and convey fewer unnecessary side effects. As genetic databases grow, genotypes will be increasingly used to discover new drug targets. At this time, the clinical application of genetics is confined to the diagnosis of and therapeutic guidance for rare forms of diabetes, as well as the prediction of adverse drug reactions. The ways in which genetics may or may not guide prevention and therapy in common forms of diabetes is unclear. However, because characterizing variation in a patient’s nuclear genome is inexpensive and easily achieved and DNA variation remains constant across the life course, it is likely that genetic sequences will feature in most patients’ clinical records. Given this, genetic data will likely be deployed in diverse ways in the diabetes clinic of the future. The roles other ‘omics technologies, digital imaging devices, and wearables will play in precision diabetes medicine are harder to forecast, as research in these areas is less advanced and the cost of obtaining some of these data will likely remain high relative to genetics. Finally, although many precision medicine initiatives focus predominantly on pharmacotherapy, optimizing lifestyle (and possibly surgical) interventions using biotechnologies also has great potential for improving type 2 diabetes prevention and treatment.

Article Information

Funding and Duality of Interest. The work of H.F. and P.W.F. related to the manuscript was supported by the European Commission (CoG-2015_681742_NASCENT), Swedish Research Council (Distinguished Young Researchers Award in Medicine), Swedish Heart-Lung Foundation, Novo Nordisk Foundation, European Foundation for the Study of Diabetes, and the Swedish Foundation for Strategic Research (Industrial Research Center in Precision Medicine) (all grants to P.W.F.). P.W.F. is a consultant for and has stock options in Zoe Global and has received research funding from Boehringer Ingelheim, Eli Lilly, Janssen, Novo Nordisk, Sanofi, and Servier. M.I.M. is a National Institute for Health Research (NIHR) Senior Investigator and a Wellcome Trust Senior Investigator. The views expressed in this article are those of the author(s) and not necessarily those of the National Health Service, NIHR, or the Department of Health. Work described in this review was principally supported by the Wellcome Trust (098381, 203141, 106130) and by the National Institutes of Health (U01-DK105535). M.I.M. serves on advisory panels for Pfizer, Novo Nordisk, and Zoe Global; has received honoraria from Pfizer, Novo Nordisk, and Eli Lilly; has stock options in Zoe Global; and has received research funding from AbbVie, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Pfizer, Roche, Sanofi, Servier, and Takeda. J.C.F. is a Massachusetts General Hospital Research Scholar and is supported by National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases grants R01 DK072041, U01 DK105554, R01 DK105154, and K24 DK110550 and National Institute of General Medical Sciences grant R01 GM117163. M.I.M., J.C.F., and P.W.F. are members of the American Diabetes Association Precision Medicine in Diabetes Taskforce. The views expressed in this article are those of the authors and do not necessarily reflect those of the American Diabetes Association or the taskforce. No other potential conflicts of interest relevant to this article were reported.

  • Received April 30, 2018.
  • for 1 last update 27 May 2020 Accepted Accepted July 7, 2018.
  • © 2018 by the American Diabetes Association.
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Readers may use this article as long as the work is properly cited, the use is educational and not for for 1 last update 27 May 2020 profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

References

  1. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA, U.S. Department of Health and Human Services, 2014
    1. Knowler WC,
    2. Fowler SE,
    3. Hamman RF, et for 1 last update 27 May 2020 alet al.; Diabetes Prevention Program Research Group
    . reverses diabetes type 2 mellitus without complication (🔴 vegetarian diet) | reverses diabetes type 2 expected findingshow to reverses diabetes type 2 for 10-year follow-up of diabetes incidence the 1 last update 27 May 2020 and weight loss in the Diabetes Prevention Program Outcomes Study10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 2009;374:16771686pmid:19878986
    1. reverses diabetes type 2 reasons (🔴 prognosis) | reverses diabetes type 2 ketohow to reverses diabetes type 2 for Li G,
    2. Zhang the 1 last update 27 May 2020 PP,
    3. Wang J, et al
    . The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 2008;reverses diabetes type 2 high blood sugar symptoms (☑ statistics australia) | reverses diabetes type 2 eating planhow to reverses diabetes type 2 for 371:17831789pmid:18502303
    1. Tuomilehto J,
    2. Lindström J,
    3. Eriksson JG, et al.; Finnish for 1 last update 27 May 2020 Diabetes Prevention Study GroupFinnish Diabetes Prevention Study Group
    . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:reverses diabetes type 2 untreated (🔴 nice) | reverses diabetes type 2 naturally with diethow to reverses diabetes type 2 for 13431350pmid:11333990
    1. for 1 last update 27 May 2020 RamachandranRamachandran A,
    2. Snehalatha C,
    3. Mary S,
    4. Mukesh B,
    5. for 1 last update 27 May 2020 BhaskarBhaskar AD,
    6. reverses diabetes type 2 guidelines (🔥 brochure) | reverses diabetes type 2 type 1how to reverses diabetes type 2 for Vijay V; Indian Diabetes Prevention Programme (IDPP)
    . The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia 2006;49:289297pmid:16391903
    1. the 1 last update 27 May 2020 LeanLean ME,
    2. reverses diabetes type 2 episode (🔴 vbid) | reverses diabetes type 2 in ushow to reverses diabetes type 2 for Leslie WS,
    3. Barnes AC, et the 1 last update 27 May 2020 alet al
    . Primary for 1 last update 27 May 2020 care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trialPrimary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet for 1 last update 27 May 2020 2018;391;541–5512018;391;541–551pmid:29221645
    1. Polyzogopoulou EV,
    2. Kalfarentzos F,
    3. Vagenakis AG,
    4. Alexandrides TK
    . Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. Diabetes 2003;52: for 1 last update 27 May 2020 109810981103 for 1 last update 27 May 2020 pmid:pmid:12716738
    1. Franco M,
    2. Orduñez P,
    3. reverses diabetes type 2 levels (🔴 vitamind3) | reverses diabetes type 2 explanationhow to reverses diabetes type 2 for Caballero B, et al
    . Impact of energy intake, physical activity, and population-wide weight loss on cardiovascular disease and diabetes mortality in Cuba, 1980-2005. Am J Epidemiol 2007;166:reverses diabetes type 2 variation (🔴 name) | reverses diabetes type 2 mellitus nature journalhow to reverses diabetes type 2 for 1374reverses diabetes type 2 vs 1 (☑ hba1c) | reverses diabetes type 2 medicine which aetna pays forhow to reverses diabetes type 2 for 1380reverses diabetes type 2 pills (🔴 yoga) | reverses diabetes type 2 nature reviewhow to reverses diabetes type 2 for pmid:17881386
    1. Cho NH,
    2. Shaw JE,
    3. Karuranga reverses diabetes type 2 kids (🔴 lawsuit) | reverses diabetes type 2 high blood sugarhow to reverses diabetes type 2 for S, et al
    . IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract the 1 last update 27 May 2020 20182018;138:271281pmid:29496507
    1. reverses diabetes type 2 treatment guidelines (🔥 go away) | reverses diabetes type 2 undiagnosedhow to reverses diabetes type 2 for Lander ES,
    2. Linton LM,
    3. Birren the 1 last update 27 May 2020 BB, et al.; International Human Genome Sequencing Consortium
    . Initial sequencing and analysis of the human genome [published correction appears in Nature 2001;411:720]. Nature 2001;409:860reverses diabetes type 2 breakfast recipes (🔴 cure) | reverses diabetes type 2 in childrenhow to reverses diabetes type 2 for 921pmid:11237011
    1. Visscher PM,
    2. reverses diabetes type 2 management (☑ treat) | reverses diabetes type 2 urinehow to reverses diabetes type 2 for Wray NR,
    3. reverses diabetes type 2 kids (🔥 explained) | reverses diabetes type 2 for dummieshow to reverses diabetes type 2 for reverses diabetes type 2 health promotion (👍 age of onset) | reverses diabetes type 2 common complicationshow to reverses diabetes type 2 for Zhang Q, et al
    . 10 Years of GWAS discovery: biology, function, and translation. Am J Hum Genet 2017;reverses diabetes type 2 therapeutic (🔥 edema) | reverses diabetes type 2 interventionhow to reverses diabetes type 2 for 101:5 the 1 last update 27 May 2020 2222reverses diabetes type 2 medications (🔥 video) | reverses diabetes type 2 coronavirus riskhow to reverses diabetes type 2 for reverses diabetes type 2 icd 10 (☑ mellitus definition) | reverses diabetes type 2 good foodhow to reverses diabetes type 2 for pmid:28686856
    1. Merino for 1 last update 27 May 2020 JJ,
    2. Udler for 1 last update 27 May 2020 MSMS,
    3. Leong A,
    4. reverses diabetes type 2 symptoms in women (🔥 paper) | reverses diabetes type 2 brochurehow to reverses diabetes type 2 for for 1 last update 27 May 2020 MeigsMeigs JB
    . A decade of genetic and metabolomic contributions to for 1 last update 27 May 2020 type 2 diabetes risk predictionA decade of genetic and metabolomic contributions to type 2 diabetes risk prediction. Curr Diab Rep 2017;17:135pmid:29103096
    1. Knowles JW,
    2. Ashley EA
    . Cardiovascular disease: the rise of the genetic risk score. PLoS Med 2018;15:e1002546pmid:29601582
    1. Mahajan A,
    2. Taliun D,
    3. Thurner M, et al
    . Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps [preprint article online], 2018. Available from https://www.biorxiv.org/content/early/2018/01/09/245506. Accessed 30 January 2018
    1. McCarthy MI
    . Painting a new picture of personalised medicine for diabetes. Diabetologia 2017;60:793799pmid:28175964
    1. Scott for 1 last update 27 May 2020 RARA,
    2. Scott LJ,
    3. Mägi R, et al.; reverses diabetes type 2 wiki (🔥 treatment nice) | reverses diabetes type 2 treatment optionshow to reverses diabetes type 2 for DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
    . An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes 2017;66:28882902pmid:28566273
    1. Mahajan AMahajan A,
    2. Wessel J,
    3. reverses diabetes type 2 natural medications (☑ untreated) | reverses diabetes type 2 obesityhow to reverses diabetes type 2 for Willems SM, reverses diabetes type 2 with diet (☑ therapeutic) | reverses diabetes type 2 for dummieshow to reverses diabetes type 2 for et al.; ExomeBP the 1 last update 27 May 2020 ConsortiumExomeBP Consortium; MAGIC Consortium; GIANT Consortium
    . Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet 2018;50:559571pmid:29632382
    1. reverses diabetes type 2 kidney (👍 hba1c) | reverses diabetes type 2 Treatmentshow to reverses diabetes type 2 for Udler MS,
    2. for 1 last update 27 May 2020 KimKim J,
    3. von Grotthuss M, reverses diabetes type 2 charts (☑ vaccine) | reverses diabetes type 2 dinner menuhow to reverses diabetes type 2 for et al
    . Clustering of type 2 diabetes genetic loci by multi-trait associations identifies disease mechanisms and subtypes [preprint article online], the 1 last update 27 May 2020 20182018. Available from https://www.biorxiv.org/content/early/2018/05/10/319509. Accessed 30 March 2018
  2. van Zuydam NR, Ahlqvist E, Sandholm N, et al. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. Diabetes 2018;67:1414–1427
    1. for 1 last update 27 May 2020 AhlqvistAhlqvist E,
    2. Storm P,
    3. Käräjämäki A, et the 1 last update 27 May 2020 alet al
    . Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster for 1 last update 27 May 2020 analysis of six variablesNovel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol 2018;6:361369pmid:29503172
    1. Fuchsberger C,
    2. Flannick J,
    3. Teslovich TM, et al
    . The genetic architecture of type 2 diabetes. Nature 2016;536:4147pmid:27398621
    1. Koivula RWKoivula RW,
    2. Heggie for 1 last update 27 May 2020 AA,
    3. Barnett reverses diabetes type 2 quote (☑ hyperglycemia) | reverses diabetes type 2 ketoacidosishow to reverses diabetes type 2 for A, et al.; reverses diabetes type 2 menu diet (👍 treatment guidelines) | reverses diabetes type 2 icd 10how to reverses diabetes type 2 for DIRECT for 1 last update 27 May 2020 ConsortiumDIRECT Consortium
    . Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia the 1 last update 27 May 2020 20142014;reverses diabetes type 2 symptoms women (⭐️ and hypothyroidism) | reverses diabetes type 2 exhaustionhow to reverses diabetes type 2 for 57:reverses diabetes type 2 statistics uk (👍 kidney pain) | reverses diabetes type 2 nursinghow to reverses diabetes type 2 for 1132 for 1 last update 27 May 2020 11421142reverses diabetes type 2 therapeutic procedures (👍 levels) | reverses diabetes type 2 with weight losshow to reverses diabetes type 2 for pmid:24695864
    1. Rask-Andersen for 1 last update 27 May 2020 MM,
    2. Karlsson for 1 last update 27 May 2020 TT,
    3. Ek WE,
    4. Johansson Å
    . reverses diabetes type 2 ribbon (🔴 veteran) | reverses diabetes type 2 exercisehow to reverses diabetes type 2 for Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status. PLoS Genet 2017;13:e1006977pmid:28873402
    1. Celis-Morales reverses diabetes type 2 overview (🔴 fatigue) | reverses diabetes type 2 younghow to reverses diabetes type 2 for CA,
    2. reverses diabetes type 2 keto diet (👍 diet uk) | reverses diabetes type 2 and obesityhow to reverses diabetes type 2 for Lyall DM,
    3. Gray the 1 last update 27 May 2020 SRSR, et al
    . Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants. Int J Obes 2017;reverses diabetes type 2 vision (🔥 causes) | reverses diabetes type 2 energyhow to reverses diabetes type 2 for the 1 last update 27 May 2020 4141:17611768pmid:28736445
    1. Tyrrell J,
    2. Wood AR,
    3. the 1 last update 27 May 2020 AmesAmes RM, et al
    . Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol 2017;46:559575pmid:28073954
    1. the 1 last update 27 May 2020 YoungYoung reverses diabetes type 2 untreated (👍 with neuropathy) | reverses diabetes type 2 food listhow to reverses diabetes type 2 for AI,
    2. Wauthier the 1 last update 27 May 2020 FF,
    3. Donnelly P
    . Multiple novel gene-by-environment interactions modify the effect of FTO variants on body for 1 last update 27 May 2020 mass indexMultiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index. Nat Commun 2016;7:12724pmid:27596730
    1. Reardon reverses diabetes type 2 oral (👍 medications) | reverses diabetes type 2 symptoms menhow to reverses diabetes type 2 for S
    . reverses diabetes type 2 foods to avoid (⭐️ kids) | reverses diabetes type 2 prognosishow to reverses diabetes type 2 for Giant study poses DNA data-sharing dilemma. Nature 2015;525:1617pmid:26333450
    1. Hudson K,
    2. Lifton RLifton R,
    3. Patrick-Lake B
    . The Precision Medicine Initiative Cohort Program – Building a Research Foundation for 21st Century Medicine. reverses diabetes type 2 lipid (🔴 pathophysiology) | reverses diabetes type 2 uncontrolled icd 10how to reverses diabetes type 2 for Bethesda, MD, National Institutes of Health, 2015
    1. Gaziano JM,
    2. Concato J,
    3. Brophy reverses diabetes type 2 your guide to getting started (🔥 insulin) | reverses diabetes type 2 youngest age in pediatricshow to reverses diabetes type 2 for M, et al
    . Million Veteran Program: a mega-biobank to study genetic influences on health and disease. J Clin Epidemiol 2016; the 1 last update 27 May 2020 7070:214223pmid:26441289
    1. Bergen reverses diabetes type 2 korean (☑ glucose range) | reverses diabetes type 2 and exercisehow to reverses diabetes type 2 for SE,
    2. Sullivan PF
    . National-scale precision medicine for psychiatric disorders in Sweden. Am J Med Genet B Neuropsychiatr Genet. 7 July 2017 [Epub ahead of print] DOI the 1 last update 27 May 2020 : 10.1002/ajmg.b.32562: 10.1002/ajmg.b.32562 the 1 last update 27 May 2020 pmid:pmid:28686353
    1. Cyranoski for the 1 last update 27 May 2020 1 last update 27 May 2020 DDCyranoski for 1 last update 27 May 2020 DD
    . China’s bid to be a DNA superpower. Nature 2016;534:462463pmid:27337326
    1. Cyranoski D
    . China embraces precision medicine on a massive scale. Nature 2016;529:910pmid:26738574
    1. Bu D,
    2. Peng the 1 last update 27 May 2020 SS,
    3. reverses diabetes type 2 snacks (🔴 diet plan printable) | reverses diabetes type 2 prognosishow to reverses diabetes type 2 for Luo H, et al
    . Precision medicine and cancer immunology in China: From big data to knowledge in precision medicine. Science the 1 last update 27 May 2020 2018 (Suppl.):S2018 (Suppl.):S for 1 last update 27 May 2020 3535–S38
    1. Moltke reverses diabetes type 2 urination (🔴 options) | reverses diabetes type 2 valueshow to reverses diabetes type 2 for I,
    2. Grarup N,
    3. reverses diabetes type 2 juice (🔴 treatment nih) | reverses diabetes type 2 therapeutichow to reverses diabetes type 2 for Jørgensen the 1 last update 27 May 2020 MEME, et al
    . A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature 2014;512: for 1 last update 27 May 2020 190190193pmid:25043022
    1. reverses diabetes type 2 treatments lexington (☑ fasting blood sugar goal) | reverses diabetes type 2 is characterized byhow to reverses diabetes type 2 for reverses diabetes type 2 quick facts (👍 info) | reverses diabetes type 2 with diethow to reverses diabetes type 2 for Dash reverses diabetes type 2 google scholar (⭐️ compared to type 1) | reverses diabetes type 2 blood sugar levelshow to reverses diabetes type 2 for S,
    2. Sano H,
    3. Rochford JJ, et al
    . A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Proc Natl Acad Sci U S A 2009;106:93509355pmid:19470471
    1. Estrada reverses diabetes type 2 quiz questions (🔥 quotes) | reverses diabetes type 2 treatmenthow to reverses diabetes type 2 for K,
    2. reverses diabetes type 2 quality of life (👍 by race) | reverses diabetes type 2 experiencehow to reverses diabetes type 2 for Aukrust I,
    3. reverses diabetes type 2 sugar (⭐️ mellitus is primarily a problem with) | reverses diabetes type 2 womenhow to reverses diabetes type 2 for Bjørkhaug L, et the 1 last update 27 May 2020 alet al.; SIGMA Type 2 Diabetes Consortium
    . Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population [published correction appears in JAMA 2014:312:1932]. JAMA the 1 last update 27 May 2020 20142014;311:23052314pmid:24915262
    1. Marshall SM
    . 60 years of metformin use: a glance at the past and a look to the future. Diabetologia 2017;60: for 1 last update 27 May 2020 156115611565pmid:28776085
    1. Pearson ER
    . Pharmacogenetics and target identification in diabetes. Curr Opin Genet Dev 2018;50:6873pmid:29486427
    1. Zhou K,
    2. reverses diabetes type 2 home remedies for (🔴 sugar) | reverses diabetes type 2 breadhow to reverses diabetes type 2 for for 1 last update 27 May 2020 BellenguezBellenguez C,
    3. Spencer for 1 last update 27 May 2020 CCCC, et for 1 last update 27 May 2020 alet al.; reverses diabetes type 2 list (☑ rise) | reverses diabetes type 2 case studyhow to reverses diabetes type 2 for GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group; reverses diabetes type 2 on insulin (👍 odor) | reverses diabetes type 2 with diethow to reverses diabetes type 2 for Wellcome Trust for 1 last update 27 May 2020 Case Control Consortium 2Wellcome Trust Case Control Consortium 2; MAGIC investigators
    . Common variants near ATM are associated with glycemic response to metformin in for 1 last update 27 May 2020 type 2 diabetesCommon variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet 2011;43:117120pmid:21186350
    1. Zhou K,
    2. Yee SW,
    3. Seiser EL, et al.; MetGen Investigators; DPP Investigators; ACCORD Investigators
    . Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet 2016;48:1055reverses diabetes type 2 events (🔥 treatments google search) | reverses diabetes type 2 onset agehow to reverses diabetes type 2 for the 1 last update 27 May 2020 10591059pmid:27500523
  3. National Research Council Committee on a Framework for Developing a New Taxonomy of Disease. Toward Precision Medicine: Building a Knowledge Network for Bomedical Research and a New Taxonomy of Disease. Washington, DC, National Academies Press, 2011
    1. Franks PW,
    2. Poveda APoveda A
    . Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy? Diabetologia 2017; the 1 last update 27 May 2020 6060:784792pmid:28124081
    1. reverses diabetes type 2 pumps system (👍 webmd) | reverses diabetes type 2 obesehow to reverses diabetes type 2 for Zeevi DZeevi D,
    2. reverses diabetes type 2 oatmeal (🔥 blood pressure) | reverses diabetes type 2 videohow to reverses diabetes type 2 for Korem T,
    3. Zmora N, et al
    . Personalized nutrition by prediction of glycemic responses. Cell 2015;163:10791094 for 1 last update 27 May 2020 pmid:pmid:26590418
  4. Swanson A. Big pharmaceutical companies are spending far more on marketing than research. The Washington Post, 11 February 2015. Available from https://www.washingtonpost.com/news/wonk/wp/2015/02/11/big-pharmaceutical-companies-are-spending-far-more-on-marketing-than-research/?noredirect=on&utm_term=.787d031b9b7c. Accessed 20 February 2018
  5. Unilever. Advertising & Marketing: Unilever, 2018. Available from http://www.unilever.com/sustainable-living/what-matters-to-you/advertising-and-marketing.html. Accessed 31 March 2018
    1. O’Dowd A
    . Spending on junk food advertising is nearly 30 times what government spends on promoting healthy eating. BMJ 2017;359:j4677pmid:29021190
    1. reverses diabetes type 2 virus (🔴 diet plan examples) | reverses diabetes type 2 weight gainhow to reverses diabetes type 2 for National Institutes of Health
    . Molecular Transducers of Physical Activity in Humans, Frequently Asked Questions (FAQs) [Internet], 2018. Available from https://commonfund.nih.gov/MolecularTransducers/FAQs. Accessed 20 March 2018
    1. reverses diabetes type 2 natural history (🔴 obese) | reverses diabetes type 2 odorhow to reverses diabetes type 2 for Livingstone the 1 last update 27 May 2020 KMKM,
    2. Celis-Morales C,
    3. Navas-Carretero for 1 last update 27 May 2020 SS, et al.; Food4Me Study
    . Effect of an Internet-based, personalized nutrition randomized trial on dietary changes associated with the Mediterranean diet: the Food4Me Study. Am J Clin Nutr 2016;104:288297pmid:27357094
    1. for 1 last update 27 May 2020 Celis-MoralesCelis-Morales reverses diabetes type 2 with intermittent fasting (☑ quick facts) | reverses diabetes type 2 and alcoholhow to reverses diabetes type 2 for C,
    2. reverses diabetes type 2 new zealand statistics (👍 questions) | reverses diabetes type 2 ankle swellinghow to reverses diabetes type 2 for Livingstone KM,
    3. Marsaux CF, et al.; Food4Me the 1 last update 27 May 2020 StudyFood4Me Study
    . Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial. Int J Epidemiol 2017;reverses diabetes type 2 uptodate (⭐️ nature review) | reverses diabetes type 2 reversalhow to reverses diabetes type 2 for 46:reverses diabetes type 2 leg pain (⭐️ josh axe) | reverses diabetes type 2 too much insulinhow to reverses diabetes type 2 for 578588pmid:27524815
    1. Celis-Morales C,
    2. Livingstone KM,
    3. Marsaux CF, et al
    . Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries. Genes Nutr 2015;10:reverses diabetes type 2 herpes (👍 prevention) | reverses diabetes type 2 natural remedieshow to reverses diabetes type 2 for 450pmid:25491748
  6. BIS Research. Global precision medicine market - analysis and forecast, 2017-2026, 2017. Available from https://bisresearch.com/industry-report/global-precision-medicine-market-2026.html. Accessed 31 January 2018
    1. Stern AD,
    2. Alexander the 1 last update 27 May 2020 BMBM,
    3. for 1 last update 27 May 2020 ChandraChandra A
    . How economics can shape precision medicines. Science the 1 last update 27 May 2020 20172017;355:11311133reverses diabetes type 2 meds (🔥 dinner recipes) | reverses diabetes type 2 meal planhow to reverses diabetes type 2 for pmid:28302813
    1. Smith RJ,
    2. Nathan DM,
    3. Arslanian SA,
    4. Groop LGroop L,
    5. Rizza RA,
    6. Rotter JI
    . Individualizing therapies in type for 1 last update 27 May 2020 2 diabetes mellitus based on patient characteristics: what we know and what we need to knowIndividualizing therapies in type 2 diabetes mellitus based on patient characteristics: what we know and what we need to know. J Clin Endocrinol Metab 2010;95:reverses diabetes type 2 your guide to getting started (🔥 vitamin d) | reverses diabetes type 2 symptoms womenhow to reverses diabetes type 2 for 15661574pmid:20194712
    1. Greeley reverses diabetes type 2 info (☑ dizziness) | reverses diabetes type 2 blood sugarhow to reverses diabetes type 2 for SA,
    2. John PM,
    3. Winn ANWinn AN, et al
    . The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes. Diabetes Care 2011; for 1 last update 27 May 2020 3434: the 1 last update 27 May 2020 622622 for 1 last update 27 May 2020 627627pmid:21273495
    1. reverses diabetes type 2 mellitus icd 10 (☑ cure) | reverses diabetes type 2 genetic linkhow to reverses diabetes type 2 for Nguyen HV,
    2. Finkelstein EA,
    3. reverses diabetes type 2 knowledge portal (☑ neuropathy treatment) | reverses diabetes type 2 treatments google searchhow to reverses diabetes type 2 for Mital S,
    4. Gardner DS
    . Incremental cost-effectiveness of algorithm-driven genetic testing versus no testing for maturity onset diabetes of the young (MODY) in Singapore. J Med Genet 2017;54:747753reverses diabetes type 2 quiz questions (🔴 vision) | reverses diabetes type 2 limitshow to reverses diabetes type 2 for pmid:28835481
    1. Naylor RN,
    2. reverses diabetes type 2 treatments lexington (🔴 risk factors) | reverses diabetes type 2 fruithow to reverses diabetes type 2 for John reverses diabetes type 2 ncbi (⭐️ cure) | reverses diabetes type 2 young adults early deathhow to reverses diabetes type 2 for PM,
    3. Winn AN, et al
    . Cost-effectiveness of MODY genetic testing: translating genomic advances into the 1 last update 27 May 2020 practical health applicationsCost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. Diabetes Care 2014;37:202209reverses diabetes type 2 physiology (⭐️ nice) | reverses diabetes type 2 usually appears after age 40how to reverses diabetes type 2 for pmid:24026547
    1. Gloyn ALGloyn AL,
    2. Pearson reverses diabetes type 2 song (⭐️ weight loss) | reverses diabetes type 2 treatment diethow to reverses diabetes type 2 for ER,
    3. Antcliff JF, et al
    . Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004;350:1838 the 1 last update 27 May 2020 18491849pmid:15115830
    1. reverses diabetes type 2 energy (👍 neuropathy) | reverses diabetes type 2 naturally with diethow to reverses diabetes type 2 for for 1 last update 27 May 2020 PearsonPearson ER,
    2. Flechtner I,
    3. Njølstad PR, et al.; Neonatal Diabetes International Collaborative Group
    . Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006;355:467477pmid:16885550
    1. UK Prospective Diabetes Study (UKPDS)
    . UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance. Diabetologia 1991; the 1 last update 27 May 2020 3434: for 1 last update 27 May 2020 877877 for 1 last update 27 May 2020 890890pmid:1778353
    1. Kesselheim AS,
    2. the 1 last update 27 May 2020 TanTan YT,
    3. Avorn J
    . The roles of academia, rare diseases, and repurposing in the development of the most transformative drugs. Health Aff (Millwood) 2015;34:286293pmid:25646109
    1. Nelson MR,
    2. Tipney the 1 last update 27 May 2020 HH,
    3. reverses diabetes type 2 pregnancy (👍 oatmeal) | reverses diabetes type 2 with neuropathyhow to reverses diabetes type 2 for Painter JL, et al
    . The support of human genetic evidence for approved drug indications. Nat Genet 2015;47:856860pmid:26121088
    1. FNIH Evidentiary Criteria Writing Group
    . Framework for Defining Evidentiary Criteria for Biomarker Qualification. Bethesda, MD, National Library of Medicine, 2016
    1. Tabák AG,
    2. Herder reverses diabetes type 2 vitamind3 (⭐️ nature) | reverses diabetes type 2 glucosehow to reverses diabetes type 2 for C,
    3. Rathmann WRathmann W,
    4. Brunner EJ,
    5. Kivimäki M
    . Prediabetes: a high-risk state for diabetes development. Lancet 2012;reverses diabetes type 2 dinner (🔥 foods to avoid) | reverses diabetes type 2 genetic linkhow to reverses diabetes type 2 for 379:22792290pmid:22683128
    1. Nicol D,
    2. Bubela T,
    3. Chalmers D, et al
    . Precision medicine: drowning in a regulatory soup? J Law Biosci 2016;3:281303
    1. Kaye J,
    2. for 1 last update 27 May 2020 WhitleyWhitley EA,
    3. Lund D,
    4. reverses diabetes type 2 oral (👍 immune system) | reverses diabetes type 2 jewelryhow to reverses diabetes type 2 for Morrison M,
    5. for 1 last update 27 May 2020 TeareTeare H,
    6. Melham KMelham K
    . Dynamic consent: a patient interface for twenty-first century research networks. Eur J Hum Genet reverses diabetes type 2 foot pain (🔴 is characterized by) | reverses diabetes type 2 graphhow to reverses diabetes type 2 for 2015;23:141 the 1 last update 27 May 2020 146146reverses diabetes type 2 korean (☑ mellitus icd 10) | reverses diabetes type 2 herpeshow to reverses diabetes type 2 for pmid:24801761
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    . Biobanks in the era of personalized medicine: objectives, challenges, and innovation: Overview. EPMA J 2016;7:4pmid:26904153
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A Global Overview of Precision Medicine in Type 2 Diabetes
Hugo Fitipaldi, Mark I. McCarthy, Jose C. Florez, Paul the 1 last update 27 May 2020 the 1 last update 27 May 2020 W. FranksPaul W. FranksHugo Fitipaldi, Mark I. McCarthy, Jose C. Florez, Paul the 1 last update 27 May 2020 W. FranksPaul W. Franks
Diabetes Oct for 1 last update 27 May 2020 2018, Oct 2018, reverses diabetes type 2 hypoglycemia (👍 natural) | reverses diabetes type 2 naturallyhow to reverses diabetes type 2 for 67 (10) 1911-1922; DOI: 10.2337/dbi17-0045

A Global Overview of Precision Medicine in Type 2 Diabetes
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