🔥+ 2diabetes10 08 Jul 2020 Diabetes mellitus due to underlying condition; E09. Drug or chemical induced diabetes mellitus; E10. Type 1 diabetes mellitus; E11. Type 2 diabetes mellitus ...

2diabetes10 "In many patients with Type 2 diabetes, the disease progresses slowly, and they may not realize that they have developed it without screening.

type 2 diabetes diagnostic procedures
The new PubMed site will become the default in mid-May. Click here to try it now! Frequently asked questions

Result Filters


Send to

Choose Destination

2diabetes10 natural supplements (🔥 diagnosis) | 2diabetes10 diagnosishow to 2diabetes10 for

  • 1 selected item: 15068125

the 1 last update 08 Jul 2020

2diabetes10 dinner recipes (⭐️ australia) | 2diabetes10 early symptomshow to 2diabetes10 for Fetching bibliography...

Generate a file for use with external citation management software.

for 1 last update 08 Jul 2020

Acta Clin Belg. 2003 Nov-Dec;58(6):335-41.

Author information

Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, Liège, Belgium. [email protected]


Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both these factors play important roles. However, the mechanisms controlling the interplay of these two impairments are unclear. A number of factors have been suggested as possibly linking insulin resistance and beta-cell dysfunction in the pathogenesis of type 2 diabetes. A majority of individuals suffering from type 2 diabetes are obese, with central visceral adiposity. Therefore, the adipose tissue should play a crucial role in the pathogenesis of type 2 diabetes. Although the predominant paradigm used to explain this link is the portal/visceral hypothesis giving a key role in elevated non-esterified fatty acid concentrations, two new emerging paradigms are the ectopic fat storage syndrome (deposition of triglycerides in muscle, liver and pancreatic cells) and the adipose tissue as endocrine organ hypothesis (secretion of various adipocytokins, i.e. leptin, TNF-alpha, resistin, adiponectin, implicated in insulin resistance and possibly beta-cell dysfunction). These two paradigms constitute the framework for the study of the interplay between insulin resistance and beta-cell dysfunction in type 2 diabetes as well as between our obesogenic environment and diabetes risk in the next decade.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

You are here: NCBI > Literature > PubMed
Support Center

Simple NCBI Directory

External link. Please review our privacy policy.

National Center for Biotechnology Information, 2diabetes10 diagnosis (☑ treatment aafp) | 2diabetes10 breakfasthow to 2diabetes10 for U.S. National Library of Medicine 2diabetes10 cramping (⭐️ limits) | 2diabetes10 permanentlyhow to 2diabetes10 for 8600 Rockville the 1 last update 08 Jul 2020 Pike8600 Rockville Pike, Bethesda MD, 20894 USA

Policies and Guidelines | Contact