Parkinson''div-gpt-ad-1450190541376-0''div-gpt-ad-1450190541376-1'' blood sugar control when it was added to the standard medication metformin for six months.
And it did so without causing hypoglycemia—blood sugar drops that, if severe, can lead to convulsions or loss of consciousness.
The findings, published Jan. 16 in the journal Science Translational Medicine, come from an earlier "" trial. And more research is needed before TTP399 can be added to existing armaments against type 2 diabetes, said senior researcher Carmen Valcarce.
But, she added, the effects seen so far on blood sugar control are comparable to, or even better than, what''s still a need for additional options, Valcarce said.
"" she for 1 last update 08 Jul 2020 noted. """" she noted. ""
Dr. Debra Simmons is an endocrinologist and professor at the 1 last update 08 Jul 2020 the University of Utah, in Salt Lake City.Dr. Debra Simmons is an endocrinologist and professor at the University of Utah, in Salt Lake City.
She agreed there''ve been stymied by side effects—not only hypoglycemia, but elevations in triglycerides (a blood fat).
Part of the problem, according to Valcarce, is that some earlier compounds affected glucokinase in both the liver and the pancreas. And when it''s team put it to the test in 190 patients with type 2 diabetes. All were already taking metformin, and some were randomly assigned to add a daily dose of TTP399. The rest of the patients added either inactive placebo pills or a diabetes drug called sitagliptin (Januvia).
After six months, patients on the new compound showed a greater reduction in their A1c level, versus placebo patients. A1c is a measure of a person''s effectiveness and safety hold up.
Simmons pointed to the bigger picture: That researchers are studying the underpinnings of diabetes and trying to develop new treatment options.
But, she stressed, ""
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