what is the diabetes blood test

🔥+ what is the diabetes blood test 02 Jun 2020 Type 2 diabetes (formerly called adult-onset or non–insulin-dependent diabetes) ... Although monitoring and managing the disease can prevent complications, ...

what is the diabetes blood test A person can suffer from either type 1 or type 2 diabetes. Both forms of the disease are considered to be metabolic disorders that affect the body's ability to ...

end of diabetes book

Find out how to listen to Dr. Pernick's podcast in People of Pathology series here.
Home > Pancreas > Non insulin dependent diabetes mellitus
what is the diabetes blood test cramping (🔥 dinner recipes) | what is the diabetes blood test mellitus with hyperglycemiahow to what is the diabetes blood test for Pancreas
Diabetes for 1 last update 02 Jun 2020 mellitusDiabetes mellitus
Non insulin dependent diabetes mellitus

Topic Completed: 1 August 2012

Minor changes: 6 March 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Non insulin dependent diabetes mellitus[TI] pancreas[TIAB]

Page views in 2019: 598
Page views in 2020 to date: 245
Table of Contents
Definition / general | Pathophysiology | Clinical features | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Videos
Cite this page: Jain D. Non insulin dependent diabetes mellitus. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/pancreasNIDDM.html. Accessed May 11th, 2020.
Definition / general
  • Also called adult onset, non insulin dependent diabetes mellitus / NIDDM, type 2
  • 80 - 90% of cases of diabetes (Wikipedia: Diabetes Mellitus Type 2 [Accessed 8 December 2017])
  • Usually > 30 years old, obese (80% of cases, abdominal obesity more important than subcutaneous obesity), normal or increased blood insulin, rare diabetic ketoacidosis, no anti-islet antibodies
  • Normal insulin secretion and plasma levels but loss of pulsatile, oscillating pattern of secretion
  • Also loss of rapid first phase of insulin secretion triggered by glucose
  • NO insulinitis is present

  • Mild / moderate insulin deficiency, may be due to beta cell damage
  • Beta cells may be "" due to chronic hyperglycemia and persistent beta cell stimulation

  • 37 amino acid peptide, normally produced by beta cells, packaged and cosecreted with insulin
  • In NIDDM patients, tends to accumulate outside beta cells and resembles amyloid
Clinical features
  • 90%+ concordance in twins, apparently due to multiple genetic polymorphisms (no HLA association)
  • Due to insulin resistance (associated with obesity and pregnancy) or derangement in beta cell secretion of insulin
  • Associated with amyloid deposits in islets (amyloid associated with basement membrane heparan sulfate proteoglycan, Arch Pathol Lab Med 1992;116:951) and pituitary (Arch Pathol Lab Med 1995;119:1055)
Microscopic (histologic) description
  • Amyloid in the islets of Langerhans is the uniform pathologic feature
Microscopic (histologic) images

Images hosted on other servers:

Amyloid for 1 last update 02 Jun 2020 deposition in isletsAmyloid deposition in islets

Islet amyloid
polypeptide and
insulin expressing
cells in islets


what is the diabetes blood test blood sugar after eating (🔥 dinner) | what is the diabetes blood test treatments and preventionshow to what is the diabetes blood test for Histopathology pancreas - type 2 diabetes mellitus

Back to top
Home > Pancreas > Non insulin dependent diabetes mellitus

30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)
Telephone: (248) 646-0325; Email: [email protected]
Sign up for our Email Newsletters

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. We are unable to respond to patient inquiries.
© Copyright PathologyOutlines.com, Inc. Click here for information on linking to our website or using our content or images.